5 Facts you should know about

ANCA-associated vasculitis

ANCA-Associated Vasculitis (AAV) comprises a group of autoimmune diseases affecting small blood vessels, including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA)

Onset typically occurs in middle age, with a peak incidence between 50 to 70 years old

Symptoms may include constitutional symptoms like fatigue, fever, weight loss, and general malaise

Common clinical manifestations involve the respiratory tract (sinusitis, pulmonary infiltrates), kidneys (hematuria, proteinuria), and systemic involvement (nerve damage, skin lesions)

Diagnosis involves clinical evaluation, serological testing for ANCA antibodies, imaging studies, and biopsy to confirm vasculitis

See our full disease profile

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