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Disease Profile
Adverse events of 5-alpha-reductase inhibitors
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
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Other names (AKA)
Post Finasteride syndrome
Summary
This page does not serve as an official recognition of post-finasteride
Treatment
Also, we recommend that you submit your symptoms to your nation's drug regulatory agency. In the United States, it is the FDA. Reporting of adverse events and medication errors is voluntary. The MedWatch site provides information about voluntary reporting.
People outside the US can find a list of international reporting agencies at the following link to the World Health Organization's Uppsala Monitoring Centre:
https://www.who-umc.org/global-pharmacovigilance/who-programme-for-international-drug-monitoring/
Currently, there is very limited information in the medical literature to guide treatment of symptoms that may occur in association with 5-alpha-reductase inhibitor use. There is little data to help a person anticipate what may be in the future in regards to their symptoms. Discuss the possible risks and benefits of your treatment given possible side effects. If you experience what you see as side effects, talk to your primary care provider about appropriate referrals to specialists, such as
The NIH funded 2 research studies to learn more about the relationship between 5-alpha-reductase inhibitors and erectile dysfunction, other sexual dysfunction (ejaculatory and psychosexual dysfunction, low libido, Peyronie's disease), breast outcomes, and depression. Researchers also investigated the persistence of symptoms and
AN EPIDEMIOLOGIC EVALUATION OF ADVERSE EVENTS OF 5-ALPHA-REDUCTASE INHIBITORS
Patient advocacy groups are another source for learning more about clinical research opportunities. You can check the Post-Finasteride
While we are not aware of a clinical research study enrolling people with adverse events from taking 5 alpha-reductase inhibitors at this time, you can periodically check the Research section of this Web page for updates. You can also consider joining a patient research registry. Patient registries collect and organize health information. They help researchers design new studies and find people who might want to participate.
ResearchMatch is a free national research registry designed to bring together patients, healthy volunteers and researchers. ResearchMatch was developed by major academic institutions across the country and is funded by the National Center for Advancing Translational Sciences, NIH.
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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Post-Finasteride Syndrome Foundation
27 World’s Fair Drive
Somerset, NJ 08873
E-mail: contact@pfsfoundation.org
Website: https://www.pfsfoundation.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The US Food and Drug Administration provides safety information on 5-alpha reductase inhibitors.
- The Post-Finasteride Syndrome Foundation provides information on this condition, including a listing of symptoms reported in association with the use of 5-alpha-reductase inhibitors.
In-Depth Information
- PubMed is a searchable database of medical literature and lists journal articles that discuss Adverse events of 5-alpha-reductase inhibitors. Click on the link to view a sample search on this topic.
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