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Adult Onset
Still's Disease

Adult-onset Still's disease is a rare systemic autoinflammatory disease characterized by the classic triad of fevers, joint pain, and a distinctive salmon-colored bumpy rash

Prevalence

3,310-29,790

US Estimated

5,135-46,215

Europe Estimated

Age of Onset

ICD-10

M06.1

Inheritance

Autosomal dominant

Autosomal recessive

Mitochondrial/Multigenic

X-linked dominant

X-linked recessive

5 Facts you should know

FACT

1

An inflammatory condition that affects multiple organs

 

FACT

2

Characterized by the classic triad of fevers, joint pain, and a distinctive salmon-colored bumpy rash

 

FACT

3

Other common symptoms include an enlarged spleen and lymph nodes, joint pain, and sore throat

 

FACT

4

Levels of the iron-binding protein ferritin are often extremely elevated

 

FACT

5

Adult-onset Still's disease is treated with anti-inflammatory medications

 

Interest over time

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Adult Onset Still's Disease is also known as...

Adult Onset Still's Disease is also known as:

  • AOSD
  • Adult Still's disease
  • Still's disease adult onset
     

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Common signs & symptoms

High fever

Joint pain

Arthritis

Skin rash

Fatigue

Enlarged spleen

Enlarged lymph nodes

High levels of ferritin in the blood

Symptoms may occur continually or over short periods of time. Arthritis can lead to permanent joint damage over time. Some people with AOSD have serious complications that include severe allergic reactions, abnormal blood clotting (disseminated intravascular coagulation), and organ failure.

Current treatments

Treatment for adult-onset Still's disease is focused on managing the symptoms and keeping them from getting worse. Several different types of medications are used including anti-inflammatory medications, steroids, and medications that help control the immune system.[4][5][6]
Specialists that may be involved in the care of someone with adult-onset Still's disease include:

Orthopedist

Rheumatologist

Dermatologist

Canakinumab(Brand name: Ilaris)

Manufactured by Novartis FDA-approved indication: ILARIS is indicated for the treatment of active Still’s disease, including Adult-Onset Still’s Disease (AOSD) and Systemic Juvenile Idiopathic Arthritis (SJIA) in patients aged 2 years and older. National Library of Medicine Drug Information Portal.

Top Clinical Trials

No clinical trials

Top Treatments in Research

No clinical trials

See full disease profile